There are many things that have to happen in order to be a human. First of all, one has to learn how to live with whatever that he/she has, just like Pip in Great Expectations, when Pip was young he learned to live with his sister and her husband without Pip ever being with his parents.
Second of all one has to go through many ups and downs throughout his/her life, just like Michelangelo in The Agony and Ecstasy did, when Michelangelo was young, he had no one to support him in sculpturing which was a down, and then Michelangelo got appreciated for his great talent when he became an adult, which was a up.
Third and final, to be human, one has to realize what is accepted by society. Something that the creature that Frankenstein had created, had learned in a very horrible way, for instance the creature got chased by villagers because he looked nothing like a human, but that the creature just looked like a "monster".